Protein Details: Cation channel sperm-associated auxiliary subunit TMEM249

Protein ID

ICDB_Pro_0911

Protein Name

Cation channel sperm-associated auxiliary subunit TMEM249

Gene Name

TMEM249; C8orfK29

Organism

Homo sapiens (Human)

Length

235 amino acids

AlphaFoldDB

AF-Q2WGJ8-F1-model_v4.pdb

Function

Auxiliary component of the CatSper complex; a complex involved in sperm cell hyperactivation.

Sequence

MPKGRAGSLPTTSIGWRFQLWFLGLTCPERHLARRLKNNSFYPFVQQEPNVFVLEYYLDTLWKGMLLFIISVVLVSFSSLREVQKQETWVFLVYGVGVGLWLVISSLPRRRLVLNHTRGVYHFSIQGRTVCQGPLHLVYVRLALSSDAHGRCFFHLVLGGHRLEPLVLVQLSEHYEQMEYLGRYIARKLNINYFDYLATSYRHVVRHWPPPGAGTVMGKSPMGHKPSSSQSSLEV

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

DOI ID

10.1038/nature04406

RefSeq

NP_001239331.1; NP_001267490.1